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Article

Emerging Links between E2F Control and Mitochondrial Function

30 Jan 2015

Abstract excerpt

The family of E2F transcription factors is the key downstream target of the retinoblastoma tumor suppressor protein (pRB), which is frequently inactivated in human cancer. E2F is best known for its role in cell-cycle regulation and triggering apoptosis. However, E2F binds to thousands of genes and, thus, could directly influence a number of biologic processes. Given the plethora of potential E2F targets, the...

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PMID: 25634216
DOI: 10.1158/0008-5472.can-14-2173

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