Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

Cell death and differentiation - 1 Jan 2011

Ingram L, Munro S, Coutts A S, La Thangue N B

Abstract excerpt

E2F activity is negatively regulated by retinoblastoma protein (pRb) through binding to the E2F-1 subunit. Within the E2F heterodimer, DP proteins are E2F partner subunits that allow proper cell cycle progression. In contrast to the other DP proteins, the newest member of the family, DP-4, downregulates E2F activity. In this study we report an unexpected role for DP-4 in regulating E2F-1 activity during the DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Structure, Tertiary

Share to Protein Subunits

Share to RNA Interference

Share to RNA, Small Interfering

Share to Transcription Factor DP1

Source

Open in PubMed Open full text

Identifiers

PMID: 20559320
DOI: 10.1038/cdd.2010.70
PMCID: PMC3131880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.PMID 20559320Read ↗

14-3-3 proteins integrate E2F activity with the DNA damage response.Semantic proximity Read ↗

Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.Semantic proximity Read ↗

Novel functions for the transcription factor E2F4 in development and diseaseSemantic proximity Read ↗

Loss of dE2F compromises mitochondrial function.Semantic proximity Read ↗

Molecular characterization of Xenopus laevis DP proteins.Semantic proximity Read ↗

Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53Semantic proximity Read ↗

E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read ↗

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.Semantic proximity Read ↗

Evolving intricacies and implications of E2F1 regulationSemantic proximity Read ↗

dDP is needed for normal cell proliferation.Semantic proximity Read ↗

Opposing roles of E2Fs in cell proliferation and deathSemantic proximity Read ↗

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.