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Article

Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice.

Nature cell biology - 1 Jul 2003

Wikonkal Norbert M, Remenyik Eva, Knezevic Dejan, Zhang Wengeng, Liu Ming, Zhao Hongyu, Berton T R, Johnson David G, Brash Douglas E

Abstract excerpt

The E2f1 transcription factor, which regulates genes required for S-phase entry, also induces apoptosis by transcriptional and post-translational mechanisms. As E2f1 is inducible by DNA damage we investigated its importance in vivo in ultraviolet (UV)-induced apoptosis, a protective mechanism that prevents the epidermis from accumulating UV-induced mutations. Contrary to expectation, E2f1-/- mice demonstrated...

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Identifiers

PMID: 12833065
DOI: 10.1038/ncb1001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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