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Article

Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex.

Cancer research - 1 Feb 2014

Al Abo Muthana, Dejsuphong Donniphat, Hirota Kouji, Yonetani Yasukazu, Yamazoe Mitsuyoshi, Kurumizaka Hitoshi, Takeda Shunichi

Abstract excerpt

BRCA1, BRCA2, and PALB2 are key players in cellular tolerance to chemotherapeutic agents, including camptothecin, cisplatin, and PARP inhibitor. The N-terminal segment of BRCA2 interacts with PALB2, thus contributing to the formation of the BRCA1-PALB2-BRCA2 complex. To understand the role played by BRCA2 in this complex, we deleted its N-terminal segment and generated BRCA2(Δ)(N) mutant cells. Although previous...

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Source

Identifiers

PMID: 24285729
DOI: 10.1158/0008-5472.CAN-13-1443

Genes

BRCA2
PALB2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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