Article
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
Current biology : CB - 24 Mar 2009
Zhang Feng, Ma Jianglin, Wu Jiaxue, Ye Lin, Cai Hong, Xia Bing, Yu Xiaochun
Abstract excerpt
BRCA1 and BRCA2 are often mutated in familial breast and ovarian cancer. Both tumor suppressors play key roles in the DNA-damage response. However, it remains unclear whether these two tumor suppressor function together in the same DNA-damage response pathway. Here, we show that BRCA1 associates with BRCA2 through PALB2/FANCN, a major binding partner of BRCA2. The interaction between BRCA1 and BRCA2 is abrogated...
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