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Article

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.

Human molecular genetics - 1 Aug 2010

Rantakari Pia, Nikkilä Jenni, Jokela Heli, Ola Roxana, Pylkäs Katri, Lagerbohm Heidi, Sainio Kirsi, Poutanen Matti, Winqvist Robert

Abstract excerpt

Mutations of the PALB2 tumor suppressor gene in humans are associated with hereditary predisposition to breast and also some other cancers. In the present study, we have characterized mice deficient in Palb2. The data show that the Palb2((+/-)) mice are normal and fertile, and lack macroscopic tumors when followed up till the age of 8 months. Homozygous (HO) Palb2((-/-)) mice present with embryonic lethality and...

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Source

Identifiers

PMID: 20484223
DOI: 10.1093/hmg/ddq207

Genes

PALB2
BRCA1
BRCA2

Provenance

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Related research

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Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.PMID 20484223Read ↗

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PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.Semantic proximity Read ↗

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.Semantic proximity Read ↗

The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.Semantic proximity Read ↗

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.Semantic proximity Read ↗

Breast cancer: PALB2--a new player in hereditary breast cancer.Semantic proximity Read ↗

PALB2 and the risks for cancer: implications for clinical care.Semantic proximity Read ↗

PALB2/FANCN: recombining cancer and Fanconi anemia.Semantic proximity Read ↗

Integrated Bioinformatics Analysis of PALB2 Reveals Expression Patterns, Molecular Interactions, and Prognostic Significance in Breast CancerSemantic proximity Read ↗

A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors.Semantic proximity Read ↗

Heterozygous mutations in PALB2 cause DNA replication and damage response defects.Semantic proximity Read ↗

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