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Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.

Cellular signalling - 1 Feb 2014

Garulli Chiara, Kalogris Cristina, Pietrella Lucia, Bartolacci Caterina, Andreani Cristina, Falconi Maurizio, Marchini Cristina, Amici Augusto

Abstract excerpt

Increasing evidence supports the theory that tumor growth, homeostasis, and recurrence are dependent on a small subset of cells with stem cell properties, redefined cancer initiating cells (CICs) or cancer stem cells. Bone morphogenetic proteins (BMPs) are involved in cell-fate specification during embryogenesis, in the maintenance of developmental potency in adult stem cells and may contribute to sustain CIC...

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Identifiers

PMID: 24280125
DOI: 10.1016/j.cellsig.2013.11.022

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CIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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