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Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status.

Cell cycle (Georgetown, Tex.) - 15 Sept 2010

Vazquez-Martin Alejandro, Oliveras-Ferraros Cristina, Cufí Silvia, Del Barco Sonia, Martin-Castillo Begoña, Menendez Javier A

Abstract excerpt

The sole overexpression of pivotal regulators of the embryonic Epithelial-Mesenchymal Transition (EMT) genetic program ("EMT status") may be sufficient to efficiently drive the ontogeny of the breast cancer stem cell molecular signature independently of changes in EMT functioning ("EMT phenotype"). Using basal-like breast cancer models naturally enriched in either CD44(pos)CD24(low/neg) or CD44(pos)CD24(pos)...

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Identifiers

PMID: 20890129

Genes

SNAI2
TWIST1
ZEB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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