Article
p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells.
Breast cancer research : BCR - 26 Oct 2012
Bisaro Brigitte, Montani Maura, Konstantinidou Georgia, Marchini Cristina, Pietrella Lucia, Iezzi Manuela, Galiè Mirco, Orso Francesca, Camporeale Annalisa, Colombo Shana M, Di Stefano Paola, Tornillo Giusy, Camacho-Leal Maria P, Turco Emilia, Taverna Daniela, Cabodi Sara, Amici Augusto, Defilippi Paola
Abstract excerpt
INTRODUCTION: Intrinsic plasticity of breast carcinoma cells allows them to undergo a transient and reversible conversion into mesenchymal cells to disseminate into distant organs, where they can re-differentiate to an epithelial-like status to form a cohesive secondary mass. The p130Cas scaffold protein is overexpressed in human ER+ and HER2+ breast cancer where it contributes to cancer progression, invasion and...
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