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Article

SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression

12 Jul 2012

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and invasion, along with epithelial stem cell properties defined by the presence of a...

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PMID: 22787120
DOI: 10.1158/0008-5472.can-12-1045

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