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Article

Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment.

International journal of molecular sciences - 29 May 2020

Ouahoud Sarah, Hardwick James C H, Hawinkels Lukas J A C

Abstract excerpt

The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult tissue homeostasis. The importance of a functional BMP pathway is underlined by various diseases, including cancer, which can arise as a consequence of dysregulated BMP signaling. Mutations in crucial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32486027
DOI: 10.3390/ijms21113888
PMCID: PMC7313454

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