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Article

CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells.

Cancer letters - 28 Apr 2016

Suyama Kumi, Onishi Hideya, Imaizumi Akira, Shinkai Kentaro, Umebayashi Masayo, Kubo Makoto, Mizuuchi Yusuke, Oda Yoshinao, Tanaka Masao, Nakamura Masafumi, Katano Mitsuo

Abstract excerpt

Hedgehog (Hh) signaling has been found to be activated in breast cancer stem cells (BCSCs). However, the precise role of the BCSCs marker, CD24, remains unclear. Here, we describe a relationship between CD24 and Sonic Hedgehog (SHH), and reveal a role for this relationship in the induction of a malignant phenotype of breast cancer. CD24 siRNA-transfected breast cancer cells (BCCs) demonstrated higher expression...

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Share to CD24 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred NOD

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Share to RNA, Small Interfering

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Source

Identifiers

PMID: 26797459
DOI: 10.1016/j.canlet.2015.12.013

Genes

SHH
STAT1
GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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