Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease.

doi:10.1371/journal.pone.0080700

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Article

Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease.

PloS one - 1 Jan 2013

Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Mäkinen Petra, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko

Abstract excerpt

Alzheimer's disease (AD) has been postulated to involve defects in the clearance of amyloid-β (Aβ). Activation of liver X receptor α (LXRα) increases the expression of apolipoprotein E (ApoE) as well as cholesterol transporters ABCA1 and ABCG1, leading to augmented clearance of Aβ. We have previously shown that the C allele of rs7120118 in the NR1H3 gene encoding LXRα reduces the risk of AD. Here, we wanted to...

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Identifiers

PMID: 24278306
DOI: 10.1371/journal.pone.0080700
PMCID: PMC3835410

Genes

APOE
ABCA1
ABCG1

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