Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.

doi:10.1016/j.neurobiolaging.2005.08.010

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Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.

Neurobiology of aging - 1 Oct 2006

Adighibe Omanma, Arepalli Sampath, Duckworth Jaime, Hardy John, Wavrant-De Vrièze Fabienne

Abstract excerpt

We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease.

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Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.

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