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Article

Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk.

Neurobiology of aging - 1 Apr 2010

Infante Jon, Rodríguez-Rodríguez Eloy, Mateo Ignacio, Llorca Javier, Vázquez-Higuera José Luis, Berciano José, Combarros Onofre

Abstract excerpt

Increasing cellular cholesterol levels results in high amyloid beta (Abeta) synthesis, which is central to the pathogenesis of Alzheimer's disease (AD). Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of...

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Identifiers

PMID: 18597895
DOI: 10.1016/j.neurobiolaging.2008.05.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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