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Article

Liver X Receptor Genes Variants Modulate ALS Phenotype.

Molecular neurobiology - 1 Mar 2018

Mouzat Kevin, Molinari Nicolas, Kantar Jovana, Polge Anne, Corcia Philippe, Couratier Philippe, Clavelou Pierre, Juntas-Morales Raul, Pageot Nicolas, Lobaccaro Jean -Marc A, Raoul Cedric, Lumbroso Serge, Camu William

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is one of the most severe motor neuron (MN) disorders in adults. Phenotype of ALS patients is highly variable and may be influenced by modulators of energy metabolism. Recent works have implicated the liver X receptors α and β (LXRs), either in the propagation process of ALS or in the maintenance of MN survival. LXRs are nuclear receptors activated by oxysterols, modulating...

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PMID: 28244008
DOI: 10.1007/s12035-017-0453-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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