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Article

Selected LDLR and APOE Polymorphisms Affect Cognitive and Functional Response to Lipophilic Statins in Alzheimer's Disease.

Journal of molecular neuroscience : MN - 1 Oct 2020

de Oliveira Fabricio Ferreira, Chen Elizabeth Suchi, Smith Marilia Cardoso, Bertolucci Paulo Henrique Ferreira

Abstract excerpt

Effects of statins over clinical changes in Alzheimer's disease (AD) are usually non-significant, but epistatic interactions between genetic variants involved in cholesterol metabolism could be important for such effects. We aimed to investigate whether LDLR single-nucleotide polymorphisms rs11669576 (LDLR8), rs5930 (LDLR10), and rs5925 (LDLR13) are associated with cognitive and functional changes in AD, while...

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Share to Alzheimer Disease
Share to Apolipoproteins E
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Share to Epistasis, Genetic
Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors
Share to Hypercholesterolemia
Share to Receptors, LDL
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PMID: 32474901
DOI: 10.1007/s12031-020-01588-7

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