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Article

No association of genetic variants of liver X receptor-beta with Alzheimer's disease risk.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2008

Rodríguez-Rodríguez Eloy, Llorca Javier, Mateo Ignacio, Infante Jon, Sánchez-Quintana Coro, García-Gorostiaga Inés, Fernández-Viadero Carlos, Peña Nicolás, Berciano José, Combarros Onofre

Abstract excerpt

Apolipoprotein E (APOE) epsilon4 allele is the strongest hitherto known risk factor for sporadic Alzheimer's disease (AD). Liver X receptor-beta (LXRbeta) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRbeta targets is APOE. To evaluate the relationship between LXRbeta genetic variants and AD, independently or in concert with the APOE...

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Source

Identifiers

PMID: 18081155
DOI: 10.1002/ajmg.b.30652

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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