An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis¹This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.

Abstract excerpt

Maspin, a member of the serpin family of serine protease inhibitors, was originally identified as a tumor suppressor that is expressed in normal mammary epithelial cells but is reduced or absent in breast carcinomas. Early enthusiasm for maspin as a biomarker for disease progression has been tempered by clinical data that associates maspin with favourable outcomes in some studies and poor prognosis in others....

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