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Article

Endogenous Inhibition of Histone Deacetylase 1 by Tumor-Suppressive Maspin

15 Sept 2006

Abstract excerpt

Maspin, a noninhibitory serine protease inhibitor, exerts multifaceted tumor-suppressive effects. Maspin expression is associated with better differentiated phenotypes, better cancer prognosis, and better drug sensitivity. Consistently, maspin also correlates with increased expression of Bax and p21WAF1/CIP1. Interestingly, histone deacetylase 1 (HDAC1), a major HDAC responsible for histone deacetylation, was...

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PMID: 16982778
DOI: 10.1158/0008-5472.can-06-1578

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