Article
Serpin mutagenesis.
Methods (San Diego, Calif.) - 1 Feb 2004
Antalis Toni M, Lawrence Daniel A
Abstract excerpt
Mutagenesis represents a powerful methodology for the analysis of protein structural and functional relationships and dissection of complex protein-protein interactions. The suicide substrate-like inhibitory mechanism of the proteins of the serpin superfamily offers unique challenges for the design of mutagenesis studies. All serpins share a well-characterized core structure and most adopt a metastable...
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