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Article

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP.

The Journal of general physiology - 1 Dec 2013

Hu Lei, Santoro Bina, Saponaro Andrea, Liu Haiying, Moroni Anna, Siegelbaum Steven

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-regulated cation (HCN) channels generate the hyperpolarization-activated cation current Ih present in many neurons. These channels are directly regulated by the binding of cAMP, which both shifts the voltage dependence of HCN channel opening to more positive potentials and increases maximal Ih at extreme negative voltages where voltage gating is complete. Here we...

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Identifiers

PMID: 24277603
DOI: 10.1085/jgp.201311013
PMCID: PMC3840918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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