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Article

Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.

The Journal of general physiology - 1 Sept 2010

Liao Zhandi, Lockhead Dean, Larson Eric D, Proenza Catherine

Abstract excerpt

The sympathetic nervous system increases heart rate by activating beta adrenergic receptors and increasing cAMP levels in myocytes in the sinoatrial node. The molecular basis for this response is not well understood; however, the cardiac funny current (I(f)) is thought to be among the end effectors for cAMP signaling in sinoatrial myocytes. I(f) is produced by hyperpolarization-activated cyclic...

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Share to Adrenergic beta-Agonists
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide-Gated Cation Channels

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Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

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Source

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Identifiers

PMID: 20713547
DOI: 10.1085/jgp.201010488
PMCID: PMC2931151

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.PMID 20713547Read ↗

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Tissue-specific N terminus of the HCN4 channel affects channel activation.Semantic proximity Read ↗

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Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.Semantic proximity Read ↗

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.Semantic proximity Read ↗

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Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.Semantic proximity Read ↗

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