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Article

Single channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D.

Channels (Austin, Tex.) - 1 Jan 2018

Thompson Emely, Eldstrom Jodene, Fedida David

Abstract excerpt

The IKs current is important in the heart's response to sympathetic stimulation. β-adrenergic stimulation increases the amount of IKs and creates a repolarization reserve that shortens the cardiac action potential duration. We have recently shown that 8-CPT-cAMP, a membrane-permeable cAMP analog, changes the channel kinetics and causes it to open more quickly and more often, as well as to higher subconductance...

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Identifiers

PMID: 30027808
DOI: 10.1080/19336950.2018.1499369
PMCID: PMC6986793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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