Article
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma.
Biochemical and biophysical research communications - 3 Oct 2014
Aoyama Ken-ichi, Ota Yoshihide, Kajiwara Kagemasa, Hirayama Noriaki, Kimura Minoru
Abstract excerpt
Recent studies showed that head and neck squamous cell carcinoma (HNSCC) including oral squamous cell carcinoma (OSCC) of Caucasian, Chinese and Indian patients frequently have NOTCH1 mutations. We found eight of 84 OSCC in Japanese patients have point mutations (9.5%) correspond to the ligand binding region of NOTCH1 protein. Two set of them are the same mutations and all mutations are non-synonymous G>A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.