Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers.

doi:10.1093/brain/awac446

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Article

Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers.

Brain : a journal of neurology - 2 May 2023

Finger Elizabeth, Malik Rubina, Bocchetta Martina, Coleman Kristy, Graff Caroline, Borroni Barbara, Masellis Mario, Laforce Robert, Greaves Caroline V, Russell Lucy L, Convery Rhian S, Bouzigues Arabella, Cash David M, Otto Markus, Synofzik Matthis, Rowe James B, Galimberti Daniela, Tiraboschi Pietro, Bartha Robert, Shoesmith Christen, Tartaglia Maria Carmela, van Swieten John C, Seelaar Harro, Jiskoot Lize C, Sorbi Sandro, Butler Chris R, Gerhard Alexander, Sanchez-Valle Raquel, de Mendonça Alexandre, Moreno Fermin, Vandenberghe Rik, Le Ber Isabelle, Levin Johannes, Pasquier Florence, Santana Isabel, Rohrer Jonathan D, Ducharme Simon

Abstract excerpt

While frontotemporal dementia has been considered a neurodegenerative disease that starts in mid-life or later, it is now clearly established that cortical and subcortical volume loss is observed more than a decade prior to symptom onset and progresses with ageing. To test the hypothesis that genetic mutations causing frontotemporal dementia have neurodevelopmental consequences, we examined the youngest adults in...

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PMID: 36458975
DOI: 10.1093/brain/awac446

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