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Article

Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD.

NeuroImage - 2 Jul 2012

Reiter Katherine, Alpert Kathryn I, Cobia Derin J, Kwasny Mary J, Morris John C, Csernansky John C, Wang Lei

Abstract excerpt

Children of Alzheimer's disease (AD) patients are at heightened risk of developing AD due to genetic influences, including the apolipoprotein E4 (ApoE4) allele. In this study, we assessed the earliest cortical changes associated with AD in 71 cognitively healthy, adult children of AD patients (AD offspring) as compared with 69 with no family history of AD (non-AD offspring). Cortical thickness measures were...

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Identifiers

PMID: 22503937
DOI: 10.1016/j.neuroimage.2012.03.083
PMCID: PMC3358455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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