Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain volume trajectories in young children are associated with polygenic scores for late-onset Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2026

Kundu Poorbita, Zhu Changbo, Huentelman Matt, Deoni Sean C L, Naymik Marcus, Taguinod Francis, De Both Matt, Lewis Candace R, Müller Hans-Georg

Abstract excerpt

INTRODUCTION: Polygenic risk scores (PRSs) for Alzheimer's disease (AD) capture an individual's genetic susceptibility to AD. Although thoroughly studied in older populations, there exists a notable gap in comprehensively exploring the association of AD PRS with early brain development. METHODS: We examined longitudinal brain magnetic resonance imaging (MRI) data from 348 typically developing children in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gray Matter

Share to Longitudinal Studies

Share to Magnetic Resonance Imaging

Share to Multifactorial Inheritance

Share to Organ Size

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 41851041
DOI: 10.1002/alz.71279
PMCID: PMC13093798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain volume trajectories in young children are associated with polygenic scores for late-onset Alzheimer's disease risk.PMID 41851041Read ↗

Multimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults.Semantic proximity Read ↗

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Semantic proximity Read ↗

A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study.Semantic proximity Read ↗

Compositional structural brain signatures capture Alzheimer’s genetic risk on brain structure along the disease<i>continuum</i>Semantic proximity Read ↗

A Phenome-Wide Association Study (Phewas) Of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results From the ABCD StudySemantic proximity Read ↗

Genetic risk for Alzheimer’s disease predicts hippocampal volume through the lifespanSemantic proximity Read ↗

Genetic risk for Alzheimer disease in children: Evidence from early-life IQ and brain white-matter microstructure.Semantic proximity Read ↗

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain agingSemantic proximity Read ↗

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain agingSemantic proximity Read ↗

Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespanSemantic proximity Read ↗

Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.Semantic proximity Read ↗

Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.