Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study.

doi:10.1001/jamaneurol.2015.1099

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Article

Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study.

JAMA neurology - 1 Aug 2015

Quiroz Yakeel T, Schultz Aaron P, Chen Kewei, Protas Hillary D, Brickhouse Michael, Fleisher Adam S, Langbaum Jessica B, Thiyyagura Pradeep, Fagan Anne M, Shah Aarti R, Muniz Martha, Arboleda-Velasquez Joseph F, Munoz Claudia, Garcia Gloria, Acosta-Baena Natalia, Giraldo Margarita, Tirado Victoria, Ramírez Dora L, Tariot Pierre N, Dickerson Bradford C, Sperling Reisa A, Lopera Francisco, Reiman Eric M

Abstract excerpt

IMPORTANCE: Brain imaging and fluid biomarkers are characterized in children at risk for autosomal dominant Alzheimer disease (ADAD). OBJECTIVE: To characterize and compare structural magnetic resonance imaging (MRI), resting-state and task-dependent functional MRI, and plasma amyloid-β (Aβ) measurements in presenilin 1 (PSEN1) E280A mutation-carrying and noncarrying children with ADAD. DESIGN, SETTING, AND...

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PMID: 26121081
DOI: 10.1001/jamaneurol.2015.1099
PMCID: PMC4625544

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PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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