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Article

Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae.

Journal of industrial microbiology - 1 Jul 1992

Brahimi-Horn M C, Luo S H, Wang S L, Gau S W, Mou D G

Abstract excerpt

The exposure of a wild-type tylosin producing strain of Streptomyces fradiae to mutagenic agents resulted in the isolation of several tylosin over-producing strains. Examination of three mutants, T4310, 612 and 3204 showed that improved tylosin production was associated with increased hydrolytic enzyme activity and cell growth. The wild-type strain showed lower levels of hydrolytic activity including, protease,...

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PMID: 1381591
DOI: 10.1007/BF01583630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae.PMID 1381591Read ↗

Characterization of mutations in regulatory genes of Tyl cluster leading to overexpression of tylosin in mutant γ-1 of Streptomyces fradiae NRRL-2702.Semantic proximity Read ↗

The tylosin-biosynthetic genes of Streptomyces fradiaeSemantic proximity Read ↗

Production of tylosin in solid-state fermentation by Streptomyces fradiae NRRL-2702 and its gamma-irradiated mutant (gamma-1).Semantic proximity Read ↗

The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.Semantic proximity Read ↗

Improvement of tylosin fermentation by mutation and medium optimization.Semantic proximity Read ↗

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin.Semantic proximity Read ↗

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.Semantic proximity Read ↗

[Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores].Semantic proximity Read ↗

[A study on space mutation of Streptomyces fradiae].Semantic proximity Read ↗

Positive control of tylosin biosynthesis: pivotal role of TylR.Semantic proximity Read ↗

Enhanced production of thrombinase by Streptomyces venezuelae: kinetic studies on growth and enzyme production of mutant strain.Semantic proximity Read ↗

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