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Article

Regulation of tylosin biosynthesis involving 'SARP-helper' activity.

Molecular microbiology - 1 Oct 2006

Bate Neil, Bignell Dawn R D, Cundliffe Eric

Abstract excerpt

Tylosin production in Streptomyces fradiae is regulated via interplay between a repressor, TylQ, and an activator of the SARP family, TylS, during regulation of tylR. The latter encodes the pathway-specific activator of the tylosin-biosynthetic (tyl) genes. Also controlled by TylS is a hitherto unassigned gene, tylU, whose product is shown here to be important for tylosin production. Thus, targeted disruption of...

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Identifiers

PMID: 16942604
DOI: 10.1111/j.1365-2958.2006.05338.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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