TLR4 polymorphisms associated with developing gastric pre-cancer lesions in a Chinese Han population.

doi:10.1016/j.humimm.2013.11.002

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Article

TLR4 polymorphisms associated with developing gastric pre-cancer lesions in a Chinese Han population.

Human immunology - 1 Feb 2014

Fan Yao-fu, Wu Yan-min, Liu Hao, Yu Yuan, Jiang Yang-yang, Xue Yu-zheng, Liu Zong-liang, Wei Mu-Xin

Abstract excerpt

Helicobacter pylori infection is a risk factor for gastric cancer. In addition, toll-like receptor 4 (TLR4) plays a fundamental role in pathogen recognition and activation of innate immunity. This study investigated the association of TLR4 polymorphisms with a risk of intestinal metaplasia (IM) and intraepithelial neoplasia (IN) in a Chinese Han population. This study analyzed TLR4 gene polymorphisms in 333...

Topics

Adult
Aged
Case-Control Studies
China
Disease Progression
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Helicobacter Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Helicobacter pylori

Humans

Immunity, Innate

Intestinal Mucosa

Intestines

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 24269697
DOI: 10.1016/j.humimm.2013.11.002

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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