Article
Polymorphisms of the TLR4 gene and risk of gastric cancer.
Gene - 1 Mar 2014
Huang Lina, Yuan Kexin, Liu Jingjing, Ren Xiyun, Dong Xiaoqun, Tian Wenjing, Jia Yunhe
Abstract excerpt
OBJECTIVE: Toll-like receptor 4 (TLR4) is an important lipo-polysaccharide (LPS) receptor in gastric epithelial cell signaling transduction and plays critical roles in the development and progression of gastric cancer (GC). We investigated the effects of TLR4 gene polymorphisms and gene-environmental interactions on the risk of GC in Northeastern China. METHODS: We genotyped two single-nucleotide polymorphisms...
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