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Article

A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors.

Gastroenterology - 1 Mar 2007

Hold Georgina L, Rabkin Charles S, Chow Wong-Ho, Smith Malcolm G, Gammon Marilie D, Risch Harvey A, Vaughan Thomas L, McColl Kenneth E L, Lissowska Jolanta, Zatonski Witold, Schoenberg Janet B, Blot William J, Mowat N Ashley G, Fraumeni Joseph F, El-Omar Emad M

Abstract excerpt

BACKGROUND AND AIMS: TLR4 is a cell-surface signaling receptor involved in the recognition and host response to Helicobacter pylori. The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis. METHODS: We assessed associations with premalignant gastric changes in 149 relatives of gastric cancer patients, including 45 with hypochlorhydria...

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Source

Identifiers

PMID: 17324405
DOI: 10.1053/j.gastro.2006.12.026

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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