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Article

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

Molecular cell - 26 Dec 2013

Sun Zheng, Feng Dan, Fang Bin, Mullican Shannon E, You Seo-Hee, Lim Hee-Woong, Everett Logan J, Nabel Christopher S, Li Yun, Selvakumaran Vignesh, Won Kyoung-Jae, Lazar Mitchell A

Abstract excerpt

Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severe hepatosteatosis. Here we show that pharmacologic HDAC inhibition in primary hepatocytes causes histone hyperacetylation but does not upregulate expression of HDAC3 target genes. Meanwhile, deacetylase-dead HDAC3 mutants can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24268577
DOI: 10.1016/j.molcel.2013.10.022
PMCID: PMC3877208

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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