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Article

Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat.

PloS one - 9 Jul 2010

Razidlo David F, Whitney Tiffany J, Casper Michelle E, McGee-Lawrence Meghan E, Stensgard Bridget A, Li Xiaodong, Secreto Frank J, Knutson Sarah K, Hiebert Scott W, Westendorf Jennifer J

Abstract excerpt

Histone deacetylase (Hdac)3 is a nuclear enzyme that contributes to epigenetic programming and is required for embryonic development. To determine the role of Hdac3 in bone formation, we crossed mice harboring loxP sites around exon 7 of Hdac3 with mice expressing Cre recombinase under the control of the osterix promoter. The resulting Hdac3 conditional knockout (CKO) mice were runted and had severe deficits in...

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Identifiers

PMID: 20628553
DOI: 10.1371/journal.pone.0011492
PMCID: PMC2901996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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