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Article

SIRT7 Is an RNA-Activated Protein Lysine Deacylase.

ACS chemical biology - 20 Jan 2017

Tong Zhen, Wang Miao, Wang Yi, Kim David D, Grenier Jennifer K, Cao Ji, Sadhukhan Sushabhan, Hao Quan, Lin Hening

Abstract excerpt

Mammalian SIRT7 is a member of the sirtuin family that regulates multiple biological processes including genome stability, metabolic pathways, stress responses, and tumorigenesis. SIRT7 has been shown to be important for ribosome biogenesis and transcriptional regulation. SIRT7 knockout mice exhibit complications associated with fatty liver and increased aging in hematopoietic stem cells. However, the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27997115
DOI: 10.1021/acschembio.6b00954
PMCID: PMC5326686

Genes

SIRT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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