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The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

23 Jul 2021

Abstract excerpt

Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this...

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PMID: 34301918
DOI: 10.1038/s41419-021-04019-6

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