Back to search

Article

Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages

2020-04-13

Abstract excerpt

<title>Abstract</title> <p>Background: Neutral cholesterol ester hydrolase 1 (NCEH1) catalyzes the hydrolysis of cholesterol ester (CE) in macrophages. Genetic ablation of NCEH1 promotes CE-laden macrophages and the development of atherosclerosis in mice. Dysregulation of NCEH1 levels is involved in the pathogenesis of multiple disorders including metabolic diseases and atherosclerosis; however, relatively little...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
886a2db8-aed6-5b68-9916-2224a194dff9
DOI
10.21203/rs.2.12171/v5
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophagesDOI 10.21203/rs.2.12171/v5
EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol EffluxSemantic proximity
RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseasesSemantic proximity
Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORαSemantic proximity
Nuclear Receptor RORα/γ: Exciting Modulators in Metabolic Syndrome and Related DisordersSemantic proximity
Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH PathogenesisSemantic proximity
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor αSemantic proximity
Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and MetabolismSemantic proximity
EHD1 regulates cholesterol homeostasis and lipid droplet storage.Semantic proximity
The roles of liver X receptor α in inflammation and inflammation‐associated diseasesSemantic proximity
Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis SusceptibilitySemantic proximity
Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular MetabolismSemantic proximity
HR3/RORα-mediated cholesterol sensing regulates TOR signalingSemantic proximity
Select a neighboring publication to make it the new centre.