Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.

The Journal of biological chemistry - 10 Jan 2014

Alaidarous Mohammed, Ve Thomas, Casey Lachlan W, Valkov Eugene, Ericsson Daniel J, Ullah M Obayed, Schembri Mark A, Mansell Ashley, Sweet Matthew J, Kobe Bostjan

Abstract excerpt

Upon activation of Toll-like receptors (TLRs), cytoplasmic Toll/interleukin-1 receptor (TIR) domains of the receptors undergo homo- or heterodimerization. This in turn leads to the recruitment of adaptor proteins, activation of transcription factors, and the secretion of pro-inflammatory cytokines. Recent studies have described the TIR domain-containing protein from Brucella melitensis, TcpB (BtpA/Btp1), to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brucella melitensis
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Differentiation Factor 88

Share to Protein Multimerization

Share to Receptors, Interleukin-1

Share to Scattering, Small Angle

Share to Toll-Like Receptor 4

Share to X-Ray Diffraction

Source

Open in PubMed Open full text

Identifiers

PMID: 24265315
DOI: 10.1074/jbc.M113.523274
PMCID: PMC3887194

Genes

TLR4
MAL
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.PMID 24265315Read ↗

The Brucella effector protein TcpB induces degradation of inflammatory caspases and thereby subverts non-canonical inflammasome activation in macrophages.Semantic proximity Read ↗

The Brucella TIR domain containing proteins BtpA and BtpB have a structural WxxxE motif important for protection against microtubule depolymerisation.Semantic proximity Read ↗

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.Semantic proximity Read ↗

Important biology events and pathways in Brucella infection and implications for novel antibiotic drug targets.Semantic proximity Read ↗

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli VirulenceSemantic proximity Read ↗

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.Semantic proximity Read ↗

Identification and Characterization of a Novel Bacterial Virulence Factor That Shares Homology with Mammalian Toll/Interleukin-1 Receptor Family ProteinsSemantic proximity Read ↗

Molecular interactions in interleukin and toll-like receptor signaling pathways.Semantic proximity Read ↗

Structural and functional understanding of the toll‐like receptorsSemantic proximity Read ↗

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 SignalingSemantic proximity Read ↗

Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.Semantic proximity Read ↗

A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.