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Article

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2013

Snyder Greg A, Cirl Christine, Jiang Jiansheng, Chen Kang, Waldhuber Anna, Smith Patrick, Römmler Franziska, Snyder Nathaniel, Fresquez Theresa, Dürr Susanne, Tjandra Nico, Miethke Thomas, Xiao Tsan Sam

Abstract excerpt

The Toll/IL-1 receptor (TIR) domains are crucial signaling modules during innate immune responses involving the Toll-like receptors (TLRs) and IL-1 receptor (IL-1R). Myeloid differential factor 88 (MyD88) is a central TIR domain-containing adapter molecule responsible for nearly all TLR-mediated signaling and is targeted by a TIR domain-containing protein C (TcpC) from virulent uropathogenic Escherichia coli, a...

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Identifiers

PMID: 23569230
DOI: 10.1073/pnas.1215770110
PMCID: PMC3637702

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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