Article
The Brucella TIR domain containing proteins BtpA and BtpB have a structural WxxxE motif important for protection against microtubule depolymerisation.
Cell communication and signaling : CCS - 12 Oct 2014
Felix Christine, Kaplan Türköz Burcu, Ranaldi Sebastien, Koelblen Thomas, Terradot Laurent, O'Callaghan David, Vergunst Annette Caroline
Abstract excerpt
BACKGROUND: The TIR domain-containing proteins BtpA/Btp1/TcpB and BtpB are translocated into host cells by the facultative intracellular bacterial pathogen Brucella. Here, they interfere with Toll like receptor signalling to temper the host inflammatory response. BtpA has also been found to modulate microtubule dynamics. In both proteins we identified a WxxxE motif, previously shown to be an essential structural...
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