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Article

The Brucella effector protein TcpB induces degradation of inflammatory caspases and thereby subverts non-canonical inflammasome activation in macrophages.

The Journal of biological chemistry - 15 Dec 2017

Jakka Padmaja, Namani Swapna, Murugan Subathra, Rai Nivedita, Radhakrishnan Girish

Abstract excerpt

The inflammasome contains intracellular receptors that recognize various pathogen-associated molecular patterns and play crucial roles in innate immune responses to invading pathogens. Non-canonical inflammasome activation is mediated by caspase-4/11, which recognizes intracellular LPS and promotes pyroptosis and secretion of proinflammatory cytokines. Brucella species are infectious intracellular pathogens that...

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Source

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Identifiers

PMID: 29061850
DOI: 10.1074/jbc.M117.815878
PMCID: PMC5733597

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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