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Article

Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.

International journal of molecular sciences - 4 Feb 2021

Thada Shruthi, Horvath Gabor L, Müller Mario M, Dittrich Nickel, Conrad Melanie L, Sur Saubashya, Hussain Abid, Pelka Karin, Gaddam Suman Latha, Latz Eicke, Slevogt Hortense, Schumann Ralf R, Burkert Sanne

Abstract excerpt

The interaction and crosstalk of Toll-like receptors (TLRs) is an established pathway in which the innate immune system recognises and fights pathogens. In a single nucleotide polymorphisms (SNP) analysis of an Indian cohort, we found evidence for both TLR4-399T and TRL8-1A conveying increased susceptibility towards tuberculosis (TB) in an interdependent manner, even though there is no established TLR4 ligand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33557133
DOI: 10.3390/ijms22041560
PMCID: PMC7913854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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