Article
A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.
Biophysical journal - 15 Sept 2015
Guven-Maiorov Emine, Keskin Ozlem, Gursoy Attila, Nussinov Ruth
Abstract excerpt
Even though the Toll-like receptor (TLR) pathway is integral to inflammatory defense mechanisms, its excessive signaling may be devastating. Cells have acquired a cascade of strategies to regulate TLR signaling by targeting protein-protein interactions, or ubiquitin chains, but the details of the inhibition mechanisms are still unclear. Here, we provide the structural basis for the regulation of TLR signaling by...
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