Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence

23 Sept 2010

Abstract excerpt

Toll-like receptor signaling requires functional Toll/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve their own survival. The TIR homologous protein TcpC was recently identified as a virulence factor in uropathogenic Escherichia coli (E. coli), suppressing innate immunity by binding to MyD88. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli research studies
Share to Immune Response and Inflammation
Share to Influenza Virus Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20886104
DOI: 10.1371/journal.ppat.1001120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli VirulencePMID 20886104Read ↗

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.Semantic proximity Read ↗

Prevalence and associations of tcpC, a gene encoding a Toll/interleukin-1 receptor domain-containing protein, among Escherichia coli urinary tract infection, skin and soft tissue infection, and commensal isolates.Semantic proximity Read ↗

TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.Semantic proximity Read ↗

Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.Semantic proximity Read ↗

Regulation of ydiV-induced biological characteristics permits Escherichia coli evasion of the host STING inflammatory response.Semantic proximity Read ↗

In Vivo Role of Two-Component Regulatory Systems in Models of Urinary Tract InfectionsSemantic proximity Read ↗

BarA-UvrY two-component system regulates virulence of uropathogenic E. coli CFT073.Semantic proximity Read ↗

Role of uropathogenic Escherichia coli outer membrane protein T in pathogenesis of urinary tract infectionSemantic proximity Read ↗

Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic ProteinSemantic proximity Read ↗

The DanRI regulatory system in uropathogenic <i>Escherichia coli</i> subverts neutrophil responsesSemantic proximity Read ↗

Two-component system GrpP/GrpQ promotes pathogenicity of uropathogenic Escherichia coli CFT073 by upregulating type 1 fimbriaSemantic proximity Read ↗

Innate Transcriptional Networks Activated in Bladder in Response to Uropathogenic Escherichia coli Drive Diverse Biological Pathways and Rapid Synthesis of IL-10 for Defense against Bacterial Urinary Tract InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.