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Article

PTEN knockdown alters dendritic spine/protrusion morphology, not density.

The Journal of comparative neurology - 1 Apr 2014

Haws Michael E, Jaramillo Thomas C, Espinosa Felipe, Widman Allie J, Stuber Garret D, Sparta Dennis R, Tye Kay M, Russo Scott J, Parada Luis F, Stavarache Mihaela, Kaplitt Michael, Bonci Antonello, Powell Craig M

Abstract excerpt

Mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are implicated in neuropsychiatric disorders including autism. Previous studies report that PTEN knockdown in neurons in vivo leads to increased spine density and synaptic activity. To better characterize synaptic changes in neurons lacking PTEN, we examined the effects of shRNA knockdown of PTEN in basolateral amygdala neurons on...

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Share to Amygdala
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Protein v-akt

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Source

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Identifiers

PMID: 24264880
DOI: 10.1002/cne.23488
PMCID: PMC3945606

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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