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Article

Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function.

Neuron - 3 Jul 2002

Murase Sachiko, Mosser Eric, Schuman Erin M

Abstract excerpt

Activity-induced changes in adhesion molecules may coordinate presynaptic and postsynaptic plasticity. Here, we demonstrate that beta-catenin, which mediates interactions between cadherins and the actin cytoskeleton, moves from dendritic shafts into spines upon depolarization, increasing its association with cadherins. beta-catenin's redistribution was mimicked or prevented by a tyrosine kinase or phosphatase...

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Source

Identifiers

PMID: 12123611
DOI: 10.1016/s0896-6273(02)00764-x

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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