Article

Morphological analysis of human and mouse dendritic spines reveals a morphological continuum and differences across ages and species

2022-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Dendritic spines have diverse morphologies, with a wide range of head and neck sizes, and these morphological differences likely generate different synaptic and functional properties. To explore how this morphological diversity differs across species we analyzed 3D confocal reconstructions of ~8,000 human spines and ~1,700 mouse spines, labeled by intracellular injections in fixed tissue. Using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd73af8d-d176-5544-905a-a8e5360c0dd5
DOI: 10.1101/2022.01.24.477510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Morphological analysis of human and mouse dendritic spines reveals a morphological continuum and differences across ages and speciesDOI 10.1101/2022.01.24.477510Read

Curvature-based machine learning method for automated segmentation of dendritic spinesSemantic proximity Read

Cortical synapses of the world’s smallest mammal: an FIB/SEM study in the Etruscan shrewSemantic proximity Read

Human outperform mouse Purkinje cells in dendritic complexity and computational capacitySemantic proximity Read

Brain-wide Organization of Post-Synaptic Sites: Three PrinciplesSemantic proximity Read

Identification of Intrinsic Features for Cortical Separability of Human and Mouse NeuronsSemantic proximity Read

Brain-wide Organization of Post-Synaptic Sites: Three PrinciplesSemantic proximity Read

Interregional human assembloids recapitulate fetal brain morphologies and enhance neuronal complexitySemantic proximity Read

Fully automated detection of dendritic spines in 3D live cell imaging data using deep convolutional neural networksSemantic proximity Read

Dendritome Mapping Unveils Spatial Organization of Striatal D1/D2-Neuron MorphologySemantic proximity Read

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.Semantic proximity Read

Regional and LTP-Dependent Variation of Synaptic Information Storage Capacity in Rat HippocampusSemantic proximity Read