Article

The impact of phosphorylated Pten at threonine 366 on cortical connectivity and behaviour

2021-09-24

Abstract excerpt

The lipid phosphatase Pten (phosphatase and tensin homologue on chromosome 10) is a key tumour suppressor gene and an important regulator of neuronal signalling. Pten mutations have been identified in patients with autism spectrum disorders, characterized by macrocephaly, impaired social interactions and communication, repetitive behaviour, intellectual disability, and epilepsy. Pten enzymatic activity is regulate...

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Literature Corpus work: 05cd1040-c86e-5840-8f1c-c4a65508eee1
DOI: 10.1101/2021.09.22.461341

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